Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-

Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  TBK1/IKKε-IN-1 is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i).

• in vivo

  TBK1/IKKε-IN-5 (40 mg/kg; p.o.; single daily for 26 days) shows good antitumor activity and prolongs survival, as well as induces immunologic memory of CT26 cells in mice when combines with anti-PD-L1^[1].

  Animal Model:	Female Balb/c mice (11 to 12-week-old; bearing CT26 tumors)[1].
  Dosage:	40 mg/kg
  Administration:	Oral gavage; single daily for 26 days (combine with anti-PD-L1).
  Result:	Exhibited greater tumor control and longer survival when combined with anti-PD-L1 than used alone of both agents Induced immunologic memory of CT26 cells in mice when combined with anti-PD-L1.

Benzonitrile, 5-[4-[[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]amino]-1,3,5-triazin-2-yl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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