OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

Bezeichnung:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

CAS-Nr88546-55-8

Englisch Name:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

CBNumberCB8505783

SummenformelC17H19N3O4S

Molgewicht361.42

MOL-Datei88546-55-8.mol

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) physikalisch-chemischer Eigenschaften

Schmelzpunkt	80-82°C
Siedepunkt	599.3±60.0 °C(Predicted)
Dichte	1.331±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
Aggregatzustand	Solid
pka	7.97±0.10(Predicted)
Farbe	White to off-white
BRN	8347309

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	2
HS Code	29333990

Gefahreninformationscode (GHS)

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC₅₀ = 18 μM).
Chemische Eigenschaften
Light Yellow Solid
Verwenden
A metabolite of Omeprazole.
Definition
ChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.
in vitro
omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].
in vivo
three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
Einzelnachweise
[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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