GANAXOLONE Struktur

GANAXOLONE

Bezeichnung:GANAXOLONE

CAS-Nr38398-32-2

Englisch Name:GANAXOLONE

CBNumberCB8498146

SummenformelC22H36O2

Molgewicht332.52

MOL-Datei38398-32-2.mol

GANAXOLONE physikalisch-chemischer Eigenschaften

Schmelzpunkt	190-192°
alpha	D +103°
Siedepunkt	434.8±18.0 °C(Predicted)
Dichte	1.036±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ~4.2 mg/mL
Aggregatzustand	solid
pka	15.18±0.70(Predicted)
Farbe	white

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	TU4384700

Gefahreninformationscode (GHS)

GANAXOLONE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABA_A receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABA_A receptor complexes containing α₁, α₂, α₃, β₂, and γ_2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.
Verwenden
Treatment of epilepsy and migraine.
Verwenden
Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.
Definition
ChEBI: Ganaxolone is a corticosteroid hormone.
Biologische Aktivität
Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
Biochem/physiol Actions
Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.
Lager
+4°C

GANAXOLONE Upstream-Materialien And Downstream Produkte

GANAXOLONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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