(R)-(-)-3-QUINUCLIDINYL BENZILATE Struktur

(R)-(-)-3-QUINUCLIDINYL BENZILATE

Bezeichnung:(R)-(-)-3-QUINUCLIDINYL BENZILATE

CAS-Nr62869-69-6

Englisch Name:(R)-(-)-3-QUINUCLIDINYL BENZILATE

CBNumberCB8496960

SummenformelC21H23NO3

Molgewicht337.41

MOL-Datei62869-69-6.mol

(R)-(-)-3-QUINUCLIDINYL BENZILATE physikalisch-chemischer Eigenschaften

storage temp.

2-8°C

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	DD4638000

Gefahreninformationscode (GHS)

(R)-(-)-3-QUINUCLIDINYL BENZILATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Quinuclidinol benzilate (QNB) aka BZ, is a white crystalline solid. Odorless to fruitlike.
Verwenden
(R)-(-)-3-Quinuclidinyl benzilate is a pharmacological agent used as muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD).
mögliche Exposition
Suspected reprotoxic hazard, drug; incapacitating agent. QNB is a glycolate anticholinergic compound that affects the CNS and peripheral nervous sys- tem (PNS) and is related to the drugs atropine, scopol- amine, and hyoscyamine. QNB is nonirritating; symptoms are delayed for several hours. QNB can be used to contami- nate water, food, and agricultural products. A highly potent drug and CNS depressant, QNB is a delayed-action inca- pacitating agent, usually dispersed as an aerosol, but it can also be used to penetrate skin when mixed with a solvent (such as DMSO), and to contaminate food and water. QNB appears to be widely used in pharmacologic research. The key to protection from QNB is prevention from entering the body with good quality aerosol filter and impermeable gloves and clothing. QMB is stable in most solvents, with a half-life of 3 to 4 weeks in moist air; it can be dispersed even with heat-producing munitions.
Versand/Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.
Inkompatibilitäten
May form explosive mixture with air. Decomposes at about 170℃ in air under prolonged heat- ing. After 1 or 2 hours at 200℃, it is completely decom- posed. Rate of decomposition is both temperature- and purity dependent. No effect on steel or stainless steel after 3 months @ 71℃. Aluminum and anodized aluminum are mildly attacked after 3 months @ 71℃. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with metals may evolve flammable hydrogen gas
Waste disposal
Dispose of the material per IAW waste disposal methods provided below. Conduct general area monitoring with an approved monitor to con- firm that the atmospheric concentrations do not exceed the airborne exposure limit. If 10 wt.% sodium hydroxide is not available then the following decontaminants may be used instead and are listed in order of preference: Decontaminating Solution No. 2 , sodium carbonate and Supertropical Bleach Slurry (STB). Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or con- taminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your local or federal environmental protection agency for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

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