Neurokinin B

Bezeichnung: Neurokinin B

CAS-Nr86933-75-7

Englisch Name: Neurokinin B

CBNumberCB8437303

SummenformelC55H79N13O14S2

Molgewicht1210.42

MOL-Datei86933-75-7.mol

Neurokinin B physikalisch-chemischer Eigenschaften

RTECS-Nr.	PC4360080
storage temp.	-20°C
Löslichkeit	Soluble to 1 mg/ml in DMSO
Aggregatzustand	Lyophilized solid.
Wasserlöslichkeit	Soluble to 0.80 mg/ml in sterile water
InChIKey	NHXYSAFTNPANFK-KWRJECPGNA-N

Sicherheit

WGK Germany

Neurokinin B Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Vertebrate tachykinins encoded by TAC3 gene (Tac2 in rodents). In 1983, Kangawa et al. isolated neurokinin B (NKB) from the porcine spinal cord and elucidated the primary sequence as Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-amide, followed by the characterization of other tetrapod NKB. In 2012, teleost NKB and its-gene-related peptide, NKF, were identified.
Definition
ChEBI: Neurokinin B is a polypeptide. It is a mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family is similar in structure and action to substance P and neurokinin A. It has the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the urinary bladder and uterus.
Biochem/physiol Actions
Neurokinin B is a ten-residue peptide. It is an endogenous tachykinin agonist with preference for the NK-3 receptor. It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.
Lager
Store at -20°C
Einzelnachweise
[1] LAUFERR. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1985, 82 21: 7444-7448. DOI:10.1073/pnas.82.21.7444.
[2] RANCENAOMI E. Neurokinin B and the hypothalamic regulation of reproduction.[J]. Brain Research, 2010, 1364: 116-128. DOI:10.1016/j.brainres.2010.08.059.
[3] MARIA ASMAT F. R M Ramzan. Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis[J]. International Journal of Peptide Research and Therapeutics, 2019, 26 1: 1259-1267. DOI:10.1007/s10989-019-09925-0.

Neurokinin B Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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