ABT 702 Dihydrochloride

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

ABT 702 Dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  adenosine (ado) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. inhibition of adenosine kinase (ak), the primary metabolic enzyme for ado, selectively increases ado concentrations at sites of tissue trauma and enhances the analgesic and antiinflammatory actions of ado. abt 702 is a novel, potent nonnucleoside ak inhibitor.

• in vitro

  abt 702 was active both in inhibiting ak (ic50 ) 1.7 nm) and ado phosphorylation in the intact cells (ic50 ) 50 nm). abt 702 was also highly selective for ak inhibition as compared to other sites of ado action including ada, ado receptors, and ado transport sites [1].

• in vivo

  abt 702 had dose-dependent antinociceptive and antiinflammatory actions in a variety of animal models of nociceptive, inflammatory, and neuropathic pain. abt 702 is the first of a novel class of potent, selective, non-nucleoside, orally active ak inhibitors that have potent antinociceptive effects in animal models [1].

• IC 50

  1.7 nm for adenosine kinase

• Einzelnachweise

  [1] lee ch, jiang m, cowart m, gfesser g, perner r, kim kh, gu yg, williams m, jarvis mf, kowaluk ea, stewart ao, bhagwat ss. discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. j med chem. 2001 jun 21;44(13):2133-8.

ABT 702 Dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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