Protopinhydrochlorid

Bezeichnung:Protopinhydrochlorid

CAS-Nr6164-47-2

Englisch Name:PROTOPINE HYDROCHLORIDE

CBNumberCB8276092

SummenformelC20H20ClNO5

Molgewicht389.83

MOL-Datei6164-47-2.mol

Synonyma

Protopinhydrochlorid

Protopinhydrochlorid physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Aggregatzustand	solid

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	36/37/39-45
RIDADR	1544
WGK Germany	3
RTECS-Nr.	UL2000000
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	6164-47-2(Hazardous Substances Data)

Gefahreninformationscode (GHS)

PROTOPINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities. It inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma at a concentration of 100 μM. Protopine inhibits contraction of isolated rat thoracic aorta induced by norepinephrine and is a non-selective inhibitor of I_Ca, I_K, I_K1, and I_Na in guinea pig ventricular myocytes. Protopine inhibits the growth of H. pylori with an MIC₅₀ value of 100 μg/ml. It reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest. Protopine (0.005 mg/kg) increases latency to first seizure in a mouse model induced by pentylenetetrazole .
Verwenden
Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.
Allgemeine Beschreibung
Protopine is a celandine alkaloid and a bioactive compound associated with the plant families including fumariaceae, berberidaceae?and papaveraceae. It is metabolized by demethylenation in the presence of the cytochrome enzymes cytochrome P450 family 2 subfamily d polypeptide 1 (CYP2D1) and cytochrome P450 family 2 subfamily c polypeptide 11 (CYP2C11).
Biochem/physiol Actions
Protopine possesses anti-parasitic, antimicrobial and anti-inflammatory property. It mediates mitotic arrest by favoring tubulin polymerization. Protopine elicits anti-invasive effects in breast cancer tumor progression.. It also provides protection against oxidative stress-induced cell death.

Protopinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6164-47-2, PROTOPINE HYDROCHLORIDE Verwandte Suche:

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