Pyrintegrin Struktur

Pyrintegrin

Bezeichnung:Pyrintegrin

CAS-Nr1228445-38-2

Englisch Name:Pyrintegrin

CBNumberCB82628330

SummenformelC23H25N5O3S

Molgewicht451.54

MOL-Datei1228445-38-2.mol

Pyrintegrin physikalisch-chemischer Eigenschaften

Siedepunkt	729.3±70.0 °C(Predicted)
Dichte	1.401±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	≤1mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
Aggregatzustand	crystalline solid
pka	9.75±0.20(Predicted)
Farbe	Off-white to light yellow

Pyrintegrin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Pyrintegrin enhances the survival of Human embryonic stem cells (hESC).
Biologische Aktivität
pyrintegrin, a 2,4-disubstituted pyrimidine, is a novel small-molecule inhibitor of bmp signaling which previously found to promote human embryonic stem cells survival [1].bone morphogenetic proteins (bmps) are members of the tgf-β superfamily of secreted signaling molecules with important roles in many biological contexts. bmps could bind to specificserine/threonine kinase receptors and transduce the signal to the nucleus through smad proteins [2].
in vitro
pyrintegrin induced differentiation of hadscs into adipogenic‐like cells in vitro. pyrintegrin drug treatment can accelerate adipocyte differentiation and augment lipid accumulation, adiponectin and fatty acid secretion in adipogenic medium differentiated human adipose derived stem cells [1]. pyrimidine (2 μm) enhanced the survival of hesc more than 30-fold after trypsin-mediated dissociation. pyrimidine increased integrin-dependent attachment of hesc to extracellular matrices without significantly impacting cell proliferation. pyrintegrin increased the binding of the activated β1 integrin-specific antibody huts-21 and enhanced the phosphorylation of multiple growth factor receptors and their downstream kinases, pi3k and mapk [3].
in vivo
pyrintegrin promoted proliferation and differentiation of adipose precursor cells depending on their microenvironment. pyrintegrin increased the number of preadipocytes and the rate of adipocyte differentiation, resulting in enhanced de novo adipogenesis [1].
Lager
Store at +4°C
Einzelnachweise
[1] shah b s. pyrintegrin induced adipogenesis: biology[d]. columbia university, 2012.
[2] von bubnoff a, cho k w y. intracellular bmp signaling regulation in vertebrates: pathway or network[j]. developmental biology, 2001, 239(1): 1-14.
[3] xu y, zhu x, hahm h s, et al. revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules[j]. proceedings of the national academy of sciences, 2010, 107(18): 8129-8134.

Pyrintegrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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