PTEROIC ACID

Bezeichnung:PTEROIC ACID

CAS-Nr119-24-4

Englisch Name:PTEROIC ACID

CBNumberCB8254618

SummenformelC14H12N6O3

Molgewicht312.28

MOL-Datei119-24-4.mol

PTEROIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	>400℃
Siedepunkt	610.0±65.0 °C(Predicted)
Dichte	1.69
storage temp.	2-8°C
Löslichkeit	Aqueous Base (Slightly), DMSO (Slightly)
pka	4.65±0.10(Predicted)
Farbe	Light Yellow to Brown

Sicherheit

WGK Germany	3
HS Code	2933599590

Gefahreninformationscode (GHS)

PTEROIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.
Verwenden
Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase.
Definition
ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid.
Allgemeine Beschreibung
Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Enzyminhibitor
This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.
läuterung methode
Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]

PTEROIC ACID Upstream-Materialien And Downstream Produkte

PTEROIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

119-24-4, PTEROIC ACID Verwandte Suche:

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