AR-42

Bezeichnung:AR-42

CAS-Nr935881-37-1

Englisch Name:AR-42

CBNumberCB82525936

SummenformelC18H20N2O3

Molgewicht312.36

MOL-Datei935881-37-1.mol

AR-42 physikalisch-chemischer Eigenschaften

Dichte	1.223
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	insoluble in EtOH; insoluble in H2O; ≥15.62 mg/mL in DMSO
Aggregatzustand	Powder
pka	8.94±0.10(Predicted)
Farbe	White to light brown

Gefahreninformationscode (GHS)

AR-42 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
AR-42 is a broad spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies. AR-42 is k nown utilized as a novel, oral cancer therapy currently in early clinical development.
Definition
ChEBI: (S)-HDAC-42 is an amidobenzoic acid.
Biologische Aktivität
ar-42 (also known as osu-hdac42), a derivative of hydroxamate-tethered phenylbutyrate, is a novel and potent inhibitor of histone deacetylase (hdac) that potently inhibits the activity of hdac with 50% inhibition concentration ic50 value of 16 nm and induces histone h3 acetylation, α-tubulin acetylation and p21 up-regulation, which have been considered as the hallmark indicators of hdac inhibition. ar-42 has been found to modulate several apoptosis inhibitors as well as cell survival regulator, including akt, bcl-xl, bax, ku70 and surviving, and exert potent antitumor activity against multiple tumor types, such as human prostate and hepatic cancers, at least partially through pi3k/akt pathway inhibition.matthew l. bush†, janet oblinger†, victoria brendel, griffin santarelli, jie huang, elena m. akhmametyeva, sarah s. burns, justin wheeler, jeremy davis, charles w. yates, abhik r. chaudhury, samuel kulp, ching-shih chen, long-sheng chang, d. bradley welling, and abraham jacob. ar42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. neuro-oncology 13(9):983–999, 2011aaron m. sargeant, robert c. rengel, samuel k. kulp, et al. osu-hdac42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model cancer res 2008;68:3999-4009.qiang lu, da-sheng wang, chang-shi chen, yuan-dong hu, and ching-shih chen. structure-based optimization of phenylbutyrate-derived histone deacetylaseinhibitors. j. med. chem. 2005, 48, 5530-5535
target
HDAC

AR-42 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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