PPT

Bezeichnung:PPT

CAS-Nr263717-53-9

Englisch Name:PPT

CBNumberCB8245076

SummenformelC24H22N2O3

Molgewicht386.44

MOL-Datei263717-53-9.mol

PPT physikalisch-chemischer Eigenschaften

Schmelzpunkt	230 °C (decomp)
Siedepunkt	630.0±55.0 °C(Predicted)
Dichte	1.24±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: 20 mg/mL, soluble
Aggregatzustand	solid
pka	8.80±0.15(Predicted)
Farbe	off-white

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

PPT Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
PPT is a potent and specific ERα agonist.
Definition
ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols.
Allgemeine Beschreibung
Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.
Biologische Aktivität
Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .
Biochem/physiol Actions
Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
Lager
+4°C

PPT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

263717-53-9, PPT Verwandte Suche:

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