1-Fluornaphthalin

Bezeichnung:1-Fluornaphthalin

CAS-Nr321-38-0

Englisch Name:1-Fluoronaphthalene

CBNumberCB8219439

SummenformelC10H7F

Molgewicht146.16

MOL-Datei321-38-0.mol

Synonyma

1-Fluornaphthalin

1-Fluornaphthalin physikalisch-chemischer Eigenschaften

Schmelzpunkt	-13 °C (lit.)
Siedepunkt	215 °C (lit.)
Dichte	1.1322 g/mL at 20 °C (lit.)
Brechungsindex	n20/D 1.593(lit.)
Flammpunkt	150 °F
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
Aggregatzustand	Oil
Farbe	Colourless to Yellow
Wichte	1.332
Wasserlöslichkeit	Not miscible or difficult to mix in water.
BRN	1906413
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	CWLKTJOTWITYSI-UHFFFAOYSA-N
CAS Datenbank	321-38-0(CAS DataBase Reference)
NIST chemische Informationen	Naphthalene, 1-fluoro-(321-38-0)
EPA chemische Informationen	1-Fluoronaphthalene (321-38-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	UN2810
WGK Germany	3
RTECS-Nr.	QJ7100000
Hazard Note	Flammable
TSCA	T
HazardClass	IRRITANT
HS Code	29039990

Gefahreninformationscode (GHS)

1-Fluoronaphthalene Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R43:Sensibilisierung durch Hautkontakt möglich.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R45:Kann Krebs erzeugen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
Chemische Eigenschaften
clear slightly yellow to yellow-brown liquid
Verwenden
1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.
synthetische
The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.
Application
1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

1-Fluoronaphthalene Upstream-Materialien And Downstream Produkte

1-Fluornaphthalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

321-38-0, 1-Fluoronaphthalene Verwandte Suche:

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