Trehalose

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Trehalose Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R38:Reizt die Haut.

• S-Sätze Betriebsanweisung:

  S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Chemische Eigenschaften

  white to off-white crystalline powder

• Chemische Eigenschaften

  Trehalose occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).

• Verwenden

  trehalose is a humectant and moisturizer, it helps bind water in the skin and increase the skin’s moisture content. It is a naturally occurring plant sugar.

• Verwenden

  D-(+)-Trehalose can be used for the effects of sucrose on blood avidity in mosquitoes.

• Definition

  ChEBI: A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.

• Vorbereitung Methode

  Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.

• Flammability and Explosibility

  Not classified

• Pharmazeutische Anwendungen

  Trehalose is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.

• Sicherheit(Safety)

  Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
  In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
  Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
  LD50 (dog, IV): >1 g/kg
  LD50 (dog, oral): >5 g/kg
  LD50 (mouse, IV): >1 g/kg
  LD50 (mouse, oral): >5 g/kg
  LD50 (rat, IV): >1 g/kg
  LD50 (rat, oral): >5 g/kg

• Lager

  Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
  Trehalose should be stored in a cool, dry place in a well-sealed container.

• Inkompatibilitäten

  Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.

• Regulatory Status

  GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.

Trehalose Upstream-Materialien And Downstream Produkte

Trehalose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(509)Suppliers

99-20-7, Trehalose Verwandte Suche: