(R)-2-Hydroxy-α-[(methylamino)methyl]-1,3,2-benzodioxaborol-5-methanol

(R)-2-hydroxy-alpha-[(methylamino)methyl]-1,3,2-benzodioxaborole-5-methanol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Eppy,Barnes Hind,US,1961

• Verwenden

  Adrenergic.

• Manufacturing Process

  Epinephrine may be made by isolation from animal adrenal glands or may be synthesized as described by Payne in Ind. Chemist, 37, 523 (1961).
  It has been found that epinephrine solutions having a physiological pH and which are stable for months in storage can be prepared by combining with the epinephrine a small amount of sodium bisulfite, boric acid, and oxine (8- hydroxy-quinoline) hereinafter called 8-quinolinol and adjusting the pH with an alkali, such as sodium hydroxide, to the desired pH.
  It has been found that from 0.001 to 0.1% of 8-quinolinol can be used. From 0.2 to 5% boric acid may be used. The amount of sodium bisulfite can be varied from 0.1 to 1%. The solutions can contain from 0.1 to 4% epinephrine. The pHs of the solutions can be adjusted to any value within the physiological range, i.e., from 6.5 to 8.5 using any convenient alkali such as sodium hydroxide.

• Trademarks

  Epinal (Alcon); Eppy/N(Pilkington Barnes Hind).

• Therapeutic Function

  Antiglaucoma

(R)-2-hydroxy-alpha-[(methylamino)methyl]-1,3,2-benzodioxaborole-5-methanol Upstream-Materialien And Downstream Produkte

(R)-2-Hydroxy-α-[(methylamino)methyl]-1,3,2-benzodioxaborol-5-methanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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