lasiocarpine Struktur

lasiocarpine

Bezeichnung:lasiocarpine

Englisch Name:lasiocarpine

CBNumberCB7875229

SummenformelC21H33NO7

Molgewicht411.49

lasiocarpine physikalisch-chemischer Eigenschaften

Schmelzpunkt	96.5-97.0℃
alpha	D -4° (10% alc)
Siedepunkt	531.2°C (rough estimate)
Dichte	1.21±0.1 g/cm3 (20 ºC 760 Torr)
Brechungsindex	1.5614 (estimate)
pka	11.99±0.29(Predicted)
Wasserlöslichkeit	6.754g/L(temperature not stated)
Stabilität	Stable, but is readily hydrolyzed in basic solution and readily oxidized by oxidizing agents. Reacts slowly with atmospheric oxygen.
LogP	1.280
IARC	2B (Vol. 10, Sup 7) 1987
EPA chemische Informationen	Lasiocarpine (303-34-4)

Sicherheit

Gefahreninformationscode (GHS)

Beschreibung
A hepatotoxic alkaloid found in Heliotropiurn lasiocarpurn, the base forms colourless leaflets from petroleum ether and has [α]²⁰_D - 4° (EtOH). It is readily soluble in C6H6 or EtOH but only slightly so in H20. On alkaline hydrolysis it furnishes angelic acid and heliotridine, C8H1302N, m.p. 116.5-118°C, forming a hydrochloride, m.p. 122-4°C and the benzoyl derivative hydrochloride, m.p. 180°C. On catalytic hydrogenation it yields a base, C13H230 2N, b.p. 123-5°Cj 8 mm; [α]_D + 3.8° (EtOH), yielding a crystalline picrate, m.p. 157 _9°C, and lasiocarpic acid, C8H160 S, m.p. 95-7°C; [α]_D + 10.6° (EtOH). The structure is therefore angelyllasiocarpylheliotridine, both hydroxyls in heliotridine being es terifie d
Chemische Eigenschaften
colourless to beige crystalline solid
Verwenden
Lasiocarpine is a hepatotoxic and carcinogenic food contaminant.
Allgemeine Beschreibung
Colorless plates or beige crystalline solid.
Air & Water Reaktionen
Decomposes slowly on standing in air at room temperature. Insoluble in water.
Reaktivität anzeigen
lasiocarpine is readily hydrolyzed by alkali. Reacts readily with oxidizing agents. Reacts slowly with atmospheric oxygen .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition lasiocarpine emits toxic fumes of nitrogen oxides.
Brandgefahr
Flash point data for lasiocarpine are not available; however, lasiocarpine is probably combustible.
Einzelnachweise
Men'shikov., Ber., 65,974 (1932)