5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

Bezeichnung:5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

CAS-Nr213261-59-7

Englisch Name:5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

CBNumberCB7839285

SummenformelC14H12O3S2

Molgewicht292.37

MOL-Datei213261-59-7.mol

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL physikalisch-chemischer Eigenschaften

Schmelzpunkt	160 °C
Siedepunkt	464.9±40.0 °C(Predicted)
Dichte	1.396±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO (up to 20 mg/ml)
pka	13.43±0.10(Predicted)
Aggregatzustand	Crystalline solid
Farbe	Yellow
Sensitive	Light Sensitive
Stabilität	Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

HS Code

29321900

Gefahreninformationscode (GHS)

Bildanzeige (GHS)
Alarmwort

Warnung
Gefahrenhinweise

H227：Combustible liquid

H302：Gesundheitsschädlich bei Verschlucken.

H315：Verursacht Hautreizungen.

H319：Verursacht schwere Augenreizung.
Sicherheit

P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

P264：Nach Gebrauch gründlich waschen.

P264：Nach Gebrauch gründlich waschen.

P270：Bei Gebrauch nicht essen, trinken oder rauchen.

P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

P337+P313：Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

P370+P378：Bei Brand: zum Löschen verwenden.

P403+P235：An einem gut belüfteten Ort aufbewahren. Kühl halten.

P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
RITA (reactivation of p53 and induction of tumor cell apoptosis, 213261-59-7) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 and preventing its proteasomal degradation.1 It also weakly (computed Kd = 22 μM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6
Verwenden
NSC 652287, a DNA damaging agent. It induces p53 tumor suppressor protein.
Verwenden
A cell-permeable, p53-targeting, tricyclic thiophene derivative
Definition
ChEBI: [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol is a member of thiophenes.
Biologische Aktivität
Anti-tumor agent that binds wild-type p53 (K d = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo .
in vitro
a number of cell lines showed a striking differential sensitivity to nsc 652287 when compared with the other cell lines in the panel, with gi50 values of 10–60 nm. the compound was found to decrease the initial number of cells by 50% (lc50) at a concentration of 100 nm in the a-498 cell line, compared with ~100 mm for the majority of the tumor cell lines. the a-498 and tk-10 cell lines were particularly sensitive to nsc 652287-induced cytotoxicity compared with achn and uo-31 cell lines [1].
in vivo
nsc 652287 was evaluated against a-498 tumor cell xenografts grown subcutaneously in nude mice. when nsc 652287 was administered twice a day, all three doses resulted in complete tumor regression in 100% of the treated mice by the end of the third treatment period. the tumors did not regrow during the remaining 40 days of the study, and no gross evidence of toxicity was observed. studies with xenografts derived from other sensitive cell lines including the renal caki-1, melanoma uacc-257, ovarian ovcar-5, and colon hcc-2998, showed moderate or minimal in vivo activity [2].
IC 50
2 nm and 20 nm for a-498 and tk-10, respectively
Lager
Store at -20°C
Einzelnachweise
Issaeva et al. (2004), Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors; Nat. Med., 10 1321 Espinoza-Fonseca et al. (2005), Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer; Theor. Biol. Med. Model, 2 38 Ristau et al. (2019), RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity; Cell Death Dis., 10 845 Zhao et al. (2010), Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA; Cell Cycle, 9 1847 Weilbacher et al. (2014), RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38; Cell Death Dis., 5 e1318 Chuang et al. (2014), The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.; PLoS One, 9(8) e104821

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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