SNC 80

SNC 80 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (K_i = 0.18 nM, IC₅₀ = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC₅₀ = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

• Chemische Eigenschaften

  Crystalline Solid

• Verwenden

  Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

• Verwenden

  A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors

• Definition

  ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.

• Biologische Aktivität

  A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors.

• Biochem/physiol Actions

  SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4

• Lager

  Store at RT

SNC 80 Upstream-Materialien And Downstream Produkte

SNC 80 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(85)Suppliers

156727-74-1, SNC 80 Verwandte Suche: