4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

• Sicherheit

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

• Synthese

  Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Upstream-Materialien And Downstream Produkte

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(227)Suppliers

206989-61-9, 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Verwandte Suche: