Rolitetracyclin

Bezeichnung:Rolitetracyclin

CAS-Nr751-97-3

Englisch Name:ROLITETRACYCLINE

CBNumberCB7666669

SummenformelC27H33N3O8

Molgewicht527.57

MOL-Datei751-97-3.mol

Synonyma

Rolitetracyclin

Rolitetracyclin physikalisch-chemischer Eigenschaften

Schmelzpunkt	163.5°C
Siedepunkt	608.16°C (rough estimate)
Dichte	1.2902 (rough estimate)
Brechungsindex	1.7120 (estimate)
storage temp.	-20°C Freezer, Under inert atmosphere
Löslichkeit	DMSO (Slightly), Methanol (Very Slightly)
Aggregatzustand	Solid
pka	pKa 7.4 (Uncertain)
Farbe	Very Dark Red to Very Dark Brown
Wasserlöslichkeit	>20g/L(21 ºC)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	1
RTECS-Nr.	QI9150000

Gefahreninformationscode (GHS)

ROLITETRACYCLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Rolitetracycline was synthesized in 1958. Bristol-Myers Laboratories prepared it from tetracycline by introducing a pyrrolidinylmethyl moiety. This antibiotic is very soluble in water and more stable than tetracycline under acidic conditions. Rolitetracycline is used by intravenous injection, and its nitrate is used by both intravenous and intramuscular injections for therapy of the same infections as those treated by tetracycline.
Verwenden
Rolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable.
Verwenden
Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.
Verwenden
neuromuscular blocker
Definition
ChEBI: A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.
Trademarks
Syntetrin (Bristol-Myers Squibb).
Allgemeine Beschreibung
Rolitetracycline, N-(pyrrolidinomethyl)tetracycline(Syntetrin), was introduced for use by intramuscular or intravenousinjection. This derivative is made by condensingtetracycline with pyrrolidine and formaldehyde in the presenceof tert-butyl alcohol. It is very soluble in water (1 g dissolvesin about 1 mL) and provides a means of injecting theantibiotic in a small volume of solution. It has been recommendedfor cases when the oral dosage forms are not suitable,but it is no longer widely used.
Pharmazeutische Anwendungen
2-N-pyrrolidinomethyl-tetracycline. A semisynthetic derivative of tetracycline supplied as the nitrate sesquihydrate for parenteral use.
It is not absorbed from the gastrointestinal tract. It is highly soluble and therefore can be administered parenterally. Peak plasma concentrations of 4–6 mg/L occur at 0.5–1 h after 350 mg intravenously. The plasma elimination half-life is 5–8 h. About 50% of the dose is excreted in the urine, producing high concentrations.
Intravenous administration is occasionally accompanied by abnormal taste, shivering and rigors, hot flushes, facial reddening, dizziness and, rarely, circulatory collapse. Symptoms of myasthenia gravis have occasionally been exacerbated.

Rolitetracyclin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

751-97-3, ROLITETRACYCLINE Verwandte Suche:

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