JNJ7777120

Bezeichnung:JNJ7777120

CAS-Nr459168-41-3

Englisch Name:JNJ7777120

CBNumberCB7503702

SummenformelC14H16ClN3O

Molgewicht277.75

MOL-Datei459168-41-3.mol

JNJ7777120 physikalisch-chemischer Eigenschaften

Siedepunkt	477.0±45.0 °C(Predicted)
Dichte	1.322±0.06 g/cm3(Predicted)
storage temp.	room temp
Löslichkeit	H₂O: insoluble
pka	15.20±0.30(Predicted)
Aggregatzustand	solid
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

JNJ7777120 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
JNJ7777120 is a histamine 4 receptor (H4R) antagonist on CCL17 and CCL22 chemokine production by human monocyte-derived Langerhans cells in patients with atopic dermatitis.
Verwenden
JNJ7777120 has been used as a histamine-4 receptor antagonist:
- to study its effects on the pro-inflammatory microglia in rats
- to study its effects on the Parkinson′s-like pathology in rat brain
- to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
Biologische Aktivität
histamine has been reported to play an important role in a large number of physiological processes. jnj-7777120, the first potent and selective non-imidazole histamine h4 receptor antagonist with ki of 4.5 nm, exhibits more than 1000-fold selectivity over the other histamine receptors. [1]
Biochem/physiol Actions
JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
in vitro
it was reported that nj 7777120 bound to the h4 receptor with a remarkably high affinity. it also demonstrated a greater selectivity over other histamine receptor antagonists. moreover, jnj 7777120 selectively targeted to potent h4 rather than 50 other molecular targets. [2]
in vivo
jnj 7777120 showed an oral bioavailability of about 30% in rats and 100% in dogs, with a half-life of around 3 h in both rats and dogs. it was reported to inhibit histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. in addition, in mice, jnj 7777120 could suppress the histamine-induced migration of tracheal mast cells from the connective tissue to the epithelium. moreover, jnj 7777120 was demonstrated to notably inhibit neutrophil infiltration in a mouse zymosan-induced peritonitis model. [2]
IC 50
a histamine h4 receptor antagonist with ic50 of 4.5 nm.
Lager
Store at +4°C
Einzelnachweise
[1]jablonowski ja, grice ca, chai w, dvorak ca, venable jd, kwok ak, ly ks, wei j, baker sm, desai pj, jiang w, wilson sj, thurmond rl, karlsson l, edwards jp, lovenberg tw and carruthers ni. the first potent and selective non-imidazole human histamine h4 receptor antagonists. j med chem. 2003 sep; 46(19): 3957-60.
[2]thurmond rl, desai pj, dunford pj, fung-leung wp, hofstra cl, jiang w, nguyen s, riley jp, sun s, williams kn, edwards jp and karlsson l. a potent and selective histamine h4 receptor antagonist with anti-inflammatory properties. j pharmacol exp ther. 2004 apr; 309(1): 404-13.

JNJ7777120 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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