Loxoribine

Bezeichnung:Loxoribine

CAS-Nr121288-39-9

Englisch Name:Loxoribine

CBNumberCB7499469

SummenformelC13H17N5O6

Molgewicht339.3

MOL-Datei121288-39-9.mol

Loxoribine physikalisch-chemischer Eigenschaften

Schmelzpunkt	227-230 °C(lit.)
Dichte	1.92±0.1 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
Löslichkeit	Soluble in DMSO (up to 25 mg/ml).
Aggregatzustand	White to off-white solid.
pka	10.29±0.20(Predicted)
Farbe	White
Optische Aktivität	[α]21/D 32°, c = 1 in H2O
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Sicherheit

WGK Germany	3
HS Code	29349990

Gefahreninformationscode (GHS)

Loxoribine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7). It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC₅₀s = 10-50, 3-20, and 13-22 μM, respectively). Loxoribine (250 μM) increases production of IL-12, IL-23, IL-27, and IL-10 by human monocyte-derived dendritic cells (MoDCs). Loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4⁺ T cells compared to control MoDCs. Loxoribine (120 mg/kg) reduces the number of pulmonary metastases in the B16 mouse model of melanoma, an effect enhanced by co-administration of IL-2, and exhibits adjuvant activity in mice immunized with a B16 tumor vaccine.
Chemische Eigenschaften
White Solid
Verwenden
Small-molecule immunostimulants
Verwenden
Loxoribine is a selective toll-like receptor 7 (TLR7) agonist that activates immune cells and increases cytokine production.
Verwenden
7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine) is a small-molecule immunostimulant. Loxoribine is a toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine product ion. Loxoribine displays antitumor and antiviral activity in various animal models.
Biologische Aktivität
Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
Einzelnachweise
1) Heil?et al.?(2003),?The Tool-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily; Eur. J. Immunol.,?33?2987 2) Goodman?et al.?(1995),?A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine;?Pharm. Biotechnol.,?6?581 3) Girart?et al.?(2007), Engagement of TLR3, TLR7 and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12; J. Immunol.,?179?3472 4) Stewart?et al.?(2012),?Toll-like receptor 7 ligands inhibit influenza A infection in chickens; J. Interferon Cytokine Res,,?32?46 5) Wang?et al.?(2015),?The TLR7 agonist induces tumor regression both by promoting CD4-T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells; Oncotarget,?6?1779

Loxoribine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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