Thymopentin

Bezeichnung:Thymopentin

CAS-Nr69558-55-0

Englisch Name:Thymopentin

CBNumberCB7491069

SummenformelC30H49N9O9

Molgewicht679.77

MOL-Datei69558-55-0.mol

Thymopentin physikalisch-chemischer Eigenschaften

Dichte	1.44±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
Aggregatzustand	Powder
pka	3.07±0.10(Predicted)
Farbe	White
CAS Datenbank	69558-55-0(CAS DataBase Reference)

Sicherheit

WGK Germany	3
HS Code	3504009000

Gefahreninformationscode (GHS)

Thymopentin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
Originator
Janssen (Belgium)
Verwenden
Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.
Verwenden
immunoregulator
Definition
ChEBI: Thymopentin is an oligopeptide.
Trademarks
SINTOMODULINA; TIMUNOX
Clinical Use
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.
Einzelnachweise
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

Thymopentin Upstream-Materialien And Downstream Produkte

Thymopentin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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