METHACHOLINE BROMIDE Struktur

Methacholinbromid

Bezeichnung:Methacholinbromid

CAS-Nr333-31-3

Englisch Name:METHACHOLINE BROMIDE

CBNumberCB7489800

SummenformelC8H18BrNO2

Molgewicht240.14

MOL-Datei333-31-3.mol

Synonyma

Methacholinbromid

Methacholinbromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	147-149 °C(lit.)
Dichte	1.3952 (rough estimate)
Brechungsindex	1.6120 (estimate)
storage temp.	-20°C
Aggregatzustand	Crystalline Powder
Farbe	White to off-white
Wasserlöslichkeit	almost transparency
Sensitive	Hygroscopic
BRN	6098010
EPA chemische Informationen	1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (333-31-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
TSCA	Yes
HS Code	29239000

Gefahreninformationscode (GHS)

METHACHOLINE BROMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
WHITE CRYSTALLINE POWDER
Verwenden
Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.
Verwenden
Methacholine is used only for bronchial hyperreactivity diagnostics. A synonym of this drug is provocholine.
Allgemeine Beschreibung
Methacholine can exist as (S) and (R) enantiomers.Although the chemical is used as the racemic mixture, itsmuscarinic activity resides principally in the (S)-isomer.The (S)/(R) ratio of muscarinic potency for these enantiomersis 240:1.
Mechanism of action
A minor structural change is the presence of a methyl group at the β-carbon atom of choline, which results in two main changes in the pharmacological profile of the molecule. Unlike acetylcholine, methacholine is hydrolyzed only by acetylcholinesterase, and the rate of hydrolysis is significantly less than with acetylcholine. Thus, the action of methacholine is significantly longer lasting than acetylcholine. Moreover, the presence of a methyl group at the β-carbon of choline provides the compound with a greater selectivity of action. Methacholine directly acts on muscarinic receptors of smooth muscle, glands,and the heart, and it has a very weak effect on nicotinic receptors of the autonomic ganglions of skeletal muscle.
Synthese
Methacholine, 1-acetoxy-2-(N,N,N-trimethyl)propyl ammonium chloride (13.1.4) or acetyl-β-methylcholine can be synthesized by any of the methods described above [8]

Methacholinbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

333-31-3, METHACHOLINE BROMIDE Verwandte Suche:

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