ANHYDROTETRACYCLINE HYDROCHLORIDE

Bezeichnung:ANHYDROTETRACYCLINE HYDROCHLORIDE

CAS-Nr13803-65-1

Englisch Name:ANHYDROTETRACYCLINE HYDROCHLORIDE

CBNumberCB7438626

SummenformelC22H23ClN2O7

Molgewicht462.88

MOL-Datei13803-65-1.mol

ANHYDROTETRACYCLINE HYDROCHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	223 °C
RTECS-Nr.	QI7860000
storage temp.	Refrigerator
Löslichkeit	Soluble in ethanol, DMSO, or DMF
Aggregatzustand	Powder
Farbe	Yellow to bright yellow
Sensitive	Moisture Sensitive
BRN	4228856
Stabilität	Hygroscopic
EPA chemische Informationen	2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	63-36
S-Sätze:	36/37/39-26
WGK Germany	3
HS Code	29413020

Gefahreninformationscode (GHS)

ANHYDROTETRACYCLINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.
Chemische Eigenschaften
yellow to bright yellow powder
Verwenden
Anhydrotetracycline is a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
Verwenden
A Tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems.
Verwenden
Anhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.

ANHYDROTETRACYCLINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

ANHYDROTETRACYCLINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13803-65-1, ANHYDROTETRACYCLINE HYDROCHLORIDE Verwandte Suche:

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