TYRPHOSTIN AG 1296

Bezeichnung:TYRPHOSTIN AG 1296

CAS-Nr146535-11-7

Englisch Name:TYRPHOSTIN AG 1296

CBNumberCB7435034

SummenformelC16H14N2O2

Molgewicht266.29

MOL-Datei146535-11-7.mol

TYRPHOSTIN AG 1296 physikalisch-chemischer Eigenschaften

Siedepunkt	420.2±40.0 °C(Predicted)
Dichte	1.192±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO.
pka	0.48±0.30(Predicted)
Aggregatzustand	White solid
Farbe	Yellow
Sensitive	Light Sensitive
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

TYRPHOSTIN AG 1296 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC₅₀ value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC₅₀ values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.
Verwenden
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
Definition
ChEBI: 6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.
target
PDGFR
Einzelnachweise
1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260 2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220 3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579

TYRPHOSTIN AG 1296 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

146535-11-7, TYRPHOSTIN AG 1296 Verwandte Suche:

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