RESINIFERATOXIN Struktur

RESINIFERATOXIN

Bezeichnung:RESINIFERATOXIN

CAS-Nr57444-62-9

Englisch Name:RESINIFERATOXIN

CBNumberCB7304594

SummenformelC37H40O9

Molgewicht628.71

MOL-Datei57444-62-9.mol

RESINIFERATOXIN physikalisch-chemischer Eigenschaften

Siedepunkt	768.7±60.0 °C(Predicted)
Dichte	1.35±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	Soluble in DMSO to 100mM and to 50mM in ethanol
Aggregatzustand	Solid
pka	9.85±0.20(Predicted)
Farbe	White to off-white
BRN	5371150
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-35
S-Sätze:	26-36/37/39-45
RIDADR	UN 2928 6.1/PG 2
WGK Germany	3
RTECS-Nr.	CY1633700
F	10-23
HazardClass	6.1(a)
PackingGroup	II
HS Code	29329990

Gefahreninformationscode (GHS)

RESINIFERATOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R35:Verursacht schwere Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM).1 Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin.2 A potent sensory neuron excitotoxin.3 Induces a long lasting analgesia in a rodent model of burn pain.4 SEVERE IRRITANT – HANDLE WITH CARE
Chemische Eigenschaften
white to off-white solid
Verwenden
Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):
- for complex preparation for cryo-electron microscopy structural studies
- to test its effect towards immune responses to?P.?aeruginosa in sensory neurons associated with the cornea
- to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice
Definition
ChEBI: Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone.
Hazard
A poison.
Biologische Aktivität
Ultrapotent analog of capsaicin that is an agonist at vanilloid receptors (K i = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
Biochem/physiol Actions
Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance. It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF).
Einzelnachweise
1) Szolcsanyi et al. (1990), Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons; J. Pharmacol. Exp. Ther., 255 923 2) Szallasi and Blumberg (1998), Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor; Life Sci. 47 1399 3) Winter et al. (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin; Brain Res. 520 131 4) Salas et al. (2017) Local Resiniferatoxin Induces Long-Lasting Analgesia in a Rat Model of Full Thickness Thermal Injury; Pain Med. 18 2453

RESINIFERATOXIN Upstream-Materialien And Downstream Produkte

RESINIFERATOXIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57444-62-9, RESINIFERATOXIN Verwandte Suche:

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