Chlorpheniramine

Chlorpheniramine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Chlorpheniramine is an antihistamine. Antihistamines are medications used to relieve symptoms of allergies, hay fever (allergic rhinitis), and the common cold. These symptoms include sneezing, runny nose, watery eyes, and itchy throat. Chlorpheniramine is sold under different brand names, including Chlor-Trimeton®.

• Verwenden

  Chlorpheniramine reduces the allergic response of the organism caused by histamine. It is used for allergy symptoms, rhinitis, and also as an ingredient in numerous compositions with ephedrine and pseudoephedrine, which are recommended for colds, upper respiratory tract infections, and allergic rhinitis. Synonyms of this drug are chlortrimeton, histaspan, tripolon, and teldrin.

• Definition

  Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. It has a role as a H1-receptor antagonist, an antipruritic drug, a histamine antagonist, a serotonin uptake inhibitor, an antidepressant and an anti-allergic agent. It is a tertiary amino compound, a member of monochlorobenzenes and a member of pyridines.

• Nebenwirkungen

  Side effects that you should report to your doctor or health care professional as soon as possible:
  allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  breathing problems
  changes in vision
  confused, agitated, nervous
  fast, irregular heartbeat
  feeling faint, dizzy
  seizures
  tremor
  trouble passing urine or change in the amount of urine
  unusual sweating
  unusually weak or tired
  Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
  constipation or diarrhea
  drowsy
  dry mouth, nose, throat
  headache
  loss of appetite
  stomach upset, vomiting
  trouble sleeping

• Synthese

  Chlorpheniramine, 3-(p-chlorophenyl)-3-(2-pyridyl)propyldimethylamine (16.1.12), is synthesized in two ways. The first is from 4-chlorbenzylcyanide, which is reacted with 2-chlorpyridine in the presence of sodium amide to form 4-chlorphenyl (2-pyridyl)acetonitrile (16.1.10). Alkylating this with 2-dimethylaminoethylchloride in the presence of sodium amide gives |?-(4-chlorphenyl)-|?-cyano-N,N-dimethyl-2-pyridinepropanamine (16.1.11), the hydrolysis and decarboxylation of which lead to chlorpheniramine (16.1.12).
  The second way is from pyridine, which undergoes alkylation by 4-chlorobenzylchloride, giving 2-(4-chlorobenzyl)pyridine (16.1.13). Alkylating this with 2-dimethylaminoethylchloride in the presence of sodium amide gives chlorpheniramine (16.1.12).

  

Chlorpheniramine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(6)Suppliers

78539-96-5, Chlorpheniramine Verwandte Suche: