COMU Struktur

COMU

Bezeichnung:COMU

CAS-Nr1075198-30-9

Englisch Name:COMU

CBNumberCB72505584

SummenformelC12H19F6N4O4P

Molgewicht428.2678402

MOL-Datei1075198-30-9.mol

COMU physikalisch-chemischer Eigenschaften

Schmelzpunkt	ca 160℃
storage temp.	Store at -15°C to -25°C.
Löslichkeit	Soluble in DMF 1mmol in 2mL.
Aggregatzustand	Powder or Solid
Farbe	White to pale yellow
Sensitive	Air & Moisture Sensitive
InChI	InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
InChIKey	GPDHNZNLPKYHCN-DZOOLQPHSA-N
SMILES	C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3
HS Code	2934 99 90

Gefahreninformationscode (GHS)

COMU Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1].
Verwenden
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible.
Verwenden
COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages
- Equal or even superior performance to HATU
- Non-explosive (does not contain benzotriazole moiety)
- Suitable for solution phase & solid phase peptide synthesis
- Utmost retention of configuration – low to non-existent racemization
- High solubility and stability in typical solvents
- Visual or colorimetric reaction monitoring possible
- Easy removal of water-soluble by-products
Allgemeine Beschreibung
This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention".
Einzelnachweise
[1] Ayman El-Faham,  Fernando Albericio. “COMU: A third generation of uronium-type coupling reagents.” Journal of Peptide Science 16 1 (2009): 6–9.

COMU Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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