PIPERLONGUMINE

Bezeichnung:PIPERLONGUMINE

CAS-Nr20069-09-4

Englisch Name:PIPERLONGUMINE

CBNumberCB7246450

SummenformelC17H19NO5

Molgewicht317.34

MOL-Datei20069-09-4.mol

PIPERLONGUMINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	124°C
Siedepunkt	475.6±45.0 °C(Predicted)
Dichte	1.223±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ≥5mg/mL at warmed to 60°C
pka	-1.88±0.20(Predicted)
Aggregatzustand	powder
Farbe	white to beige
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
LogP	2.340 (est)

Sicherheit

WGK Germany	3
RTECS-Nr.	UU7785850
HS Code	2932209090

Gefahreninformationscode (GHS)

PIPERLONGUMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.
Verwenden
anti-asthma, antibronchitis
Verwenden
Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.
Verwenden
Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.
Definition
ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.
Allgemeine Beschreibung
Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.
Biochem/physiol Actions
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.
target
P450 (e.g. CYP17) | Antifection
Einzelnachweise
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)

PIPERLONGUMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

20069-09-4, PIPERLONGUMINE Verwandte Suche:

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