NOMIFENSINE MALEATE SALT Struktur

8-Ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinoliniummaleat

Bezeichnung:8-Ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinoliniummaleat

CAS-Nr32795-47-4

Englisch Name:NOMIFENSINE MALEATE SALT

CBNumberCB7202667

SummenformelC16H18N2.C4H4O4

Molgewicht354.4

MOL-Datei32795-47-4.mol

Synonyma

8-Ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinoliniummaleat

8-Ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinoliniummaleat physikalisch-chemischer Eigenschaften

Schmelzpunkt	199-201°
storage temp.	Refrigerator, Under Inert Atmosphere
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand	Solid
Farbe	Crystals from EtOH
Wasserlöslichkeit	Water : 2.2 mg/mL (6.21 mM; Need ultrasonic)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
RIDADR	3249
WGK Germany	3
RTECS-Nr.	NX4912800
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973)

Gefahreninformationscode (GHS)

NOMIFENSINE MALEATE SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Pale Yellow Solid
Originator
Alival,Hoechst,W. Germany ,1976
Verwenden
Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.
Verwenden
A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.
Verwenden
Antidepressant;Dopamine uptake inhibitor
Manufacturing Process
A solution of N-(2-aminobenzyl)-1-phenyl-2-methylaminoethanol-1 was prepared by the reaction of α-bromo-acetophenone and (2nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickel on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. By extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-isoquinoline. The base is reacted with maleic acid to give the maleate; melting point of the maleate 199° to 201°C (from ethanol).
Trademarks
Merital (Hoechst-Roussel).
Therapeutic Function
Psychostimulant
Biochem/physiol Actions
Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.
Sicherheitsprofil
Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Human systemic effects by intravenous route: heart ratechanges, blood pressure elevation. Experimentalreproductive effects. An antidepressant. When heated to decomposition it em
Lager
Store at +4°C

NOMIFENSINE MALEATE SALT Upstream-Materialien And Downstream Produkte

8-Ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinoliniummaleat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

32795-47-4, NOMIFENSINE MALEATE SALT Verwandte Suche:

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