5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  23145-07-5

  

  73183-34-3

  

  519054-55-8

  Under nitrogen protection, 5-bromobenzofuran (25 g, 0.126 mol), pinacol ester of bisboronic acid (38.67 g, 0.152 mol), Pd(dppf)Cl2 (3.11 g, 3 mol%), KOAc (37.36 g, 0.381 mol) and 1,4-dioxane (500 ml) were mixed. The reaction mixture was stirred at 130°C for 12 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous MgSO4. Purification by column chromatography (eluent: hexane/ethyl acetate=10:1, v/v) afforded 2-(benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (23.23 g, 75% yield).

• Einzelnachweise

  [1] Patent: JP2016/40292, 2016, A. Location in patent: Paragraph 0518-0520
  [2] Patent: JP2015/527347, 2015, A. Location in patent: Paragraph 0131; 0132
  [3] Patent: KR101599586, 2016, B1. Location in patent: Paragraph 0170-0174
  [4] Patent: KR101879905, 2018, B1. Location in patent: Paragraph 1187-1191
  [5] Organometallics, 2016, vol. 35, # 10, p. 1559 - 1564

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran Upstream-Materialien And Downstream Produkte

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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