ACETYLENEDICARBOXAMIDE

Bezeichnung:ACETYLENEDICARBOXAMIDE

CAS-Nr543-21-5

Englisch Name:ACETYLENEDICARBOXAMIDE

CBNumberCB7103786

SummenformelC4H4N2O2

Molgewicht112.09

MOL-Datei543-21-5.mol

ACETYLENEDICARBOXAMIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	179 °C
Siedepunkt	209.98°C (rough estimate)
Dichte	1.4421 (rough estimate)
Brechungsindex	1.4610 (estimate)
storage temp.	Store at -20°C
Löslichkeit	DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
Aggregatzustand	Fine Crystalline Powder
pka	13.01±0.50(Predicted)
Farbe	Cream to beige
EPA chemische Informationen	2-Butynediamide (543-21-5)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-21
S-Sätze:	45-36/37-28A
HS Code	29241900
Toxizität	LD50 i.v. in mice: 11 mg/kg (Suzuki)

Gefahreninformationscode (GHS)

ACETYLENEDICARBOXAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R21:Gesundheitsschädlich bei Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC₅₀s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle. Formulations containing cellocidin have been used as agricultural pesticides.
Chemische Eigenschaften
CREAM TO BEIGE FINE CRYSTALLINE POWDER
Verwenden
Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.
Definition
ChEBI: A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.
läuterung methode
Acetylenedicarboxamide crystallises from MeOH and H2O [m 190-192o(dec) as hemihydrate]. When prepared from the ester + NH3 it has m 213o(dec). Also a melting point of 290-292o(dec) has been reported. [Saggimo J Org Chem 22 1171 1857, Kharash et al. J Org Chem 10 392 1945, Blomquist & Winslow J Org Chem 10 156 1945, Beilstein 2 I 317, 2 III 1995, 2 IV 2295.]

ACETYLENEDICARBOXAMIDE Upstream-Materialien And Downstream Produkte

ACETYLENEDICARBOXAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

543-21-5, ACETYLENEDICARBOXAMIDE Verwandte Suche:

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