Sovilnesib

Sovilnesib Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.

• in vitro

  Sovilnesib is a kinesin-like protein KIF18A inhibitor.

• in vivo

  Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.

• Clinical claims and research

  Sovilnesib (AMG-650) is under development for the treatment of triple-negative breast cancer (TNBC), platinum-resistant high grade serous ovarian cancer, primary peritoneal cancer, fallopian tube cancer, serous endometrial cancer and other solid tumors with TP53 gene mutation (TP53MUT). The drug candidate is administered orally as tablet. It acts by targeting KIF18A.

Sovilnesib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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