2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine

Bezeichnung:2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine

Englisch Name:2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine

CBNumberCB6699657

SummenformelC10H13N3

Molgewicht175.23

2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine physikalisch-chemischer Eigenschaften

Schmelzpunkt	142-146 °C
Siedepunkt	279.7±23.0 °C(Predicted)
Dichte	1.18±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO, Methanol
pka	8.89±0.40(Predicted)
Aggregatzustand	Solid
Farbe	Pale Yellow

Gefahreninformationscode (GHS)

Beschreibung
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.
Chemische Eigenschaften
Off-white powder
Verwenden
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is used as building block in chemical synthesis. Attributes Development Product Contact
Verwenden
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (cas# 133240-06-9) is a compound useful in organic synthesis.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 5775, 1994 DOI: 10.1016/S0040-4039(00)78181-0
in vitro
in a previous study, 2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridine was synthezed by reduction of 2-amino-3-nitropyridine derivatives to the corresponding diaminopyridine which was then condensed with an appropriate carboxylic acid in polyphosphoric acid. in vitro activity study showed that 2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridine was a nonpeptidic angiotensin ii receptor antagonist whose imidazo[4,5-b]pyridine scaffold had been used to examine plenty of positional substitutions in the development of orally active, long duration antihypertensive agents [1].
Einzelnachweise
[1] mantlo, n. b.,chakravarty, p.k.,ondeyka, d.l., et al. potent, orally active imadazo[4,5-b]pyridine-based angiotensin ii receptor antagonists. journal of medicinal chemistry 34(9), 2919-2922 (1991).