Suberohydroxamic acid

Bezeichnung:Suberohydroxamic acid

CAS-Nr38937-66-5

Englisch Name:Suberohydroxamic acid

CBNumberCB6673028

SummenformelC8H16N2O4

Molgewicht204.22

MOL-Datei38937-66-5.mol

Suberohydroxamic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	153-155 °C(lit.)
Dichte	1.219±0.06 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	H₂O: soluble
pka	9.18±0.20(Predicted)
Aggregatzustand	lyophilized powder
Farbe	White to Light Beige
Stabilität	Hygroscopic

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
HS Code	2928009090

Suberohydroxamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.
Verwenden
Inhibits histone deacetylation.
Verwenden
Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.
Definition
ChEBI: N,N'-dihydroxyoctanediamide is a hydroxamic acid.
Biologische Aktivität
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Einzelnachweise
1. richon vm, emiliani s, verdin e et al. a class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. proc natl acad sci u s a. 1998 mar 17; 95(6):3003-7.2. zhang xd, gillespie sk, borrow jm, hersey p. the histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. mol cancer ther. 2004 apr; 3(4):425-35.

Suberohydroxamic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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