OSELTAMIVIR ACID

Bezeichnung:OSELTAMIVIR ACID

CAS-Nr187227-45-8

Englisch Name:OSELTAMIVIR ACID

CBNumberCB6501589

SummenformelC14H24N2O4

Molgewicht284.35

MOL-Datei187227-45-8.mol

OSELTAMIVIR ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	183-185°C
Siedepunkt	508.7±50.0 °C(Predicted)
Dichte	1.15±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	≥14.2 mg/mL in DMSO; ≥46.1 mg/mL in H2O with gentle warming; ≥97 mg/mL in EtOH with gentle warming
Aggregatzustand	Solid
pka	4.13±0.60(Predicted)
Farbe	White to off-white
EPA chemische Informationen	1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, (3R,4R,5S)- (187227-45-8)

Sicherheit

HS Code

9999999999

Gefahreninformationscode (GHS)

OSELTAMIVIR ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Oseltamivir (GS-4104) is an antiviral prodrug targeted against the influenza viruses. Oseltamivir acid is the active metabolite of oseltamivir. It acts as an inhibitor of influenza neuraminidases A and B (IC₅₀ = 0.1 to 4.9 nM for both enzymes), in this way preventing virus budding and release.
Chemische Eigenschaften
White Solid
Verwenden
Oseltamivir Acid is a metabolite of Oseltamivir (O701000).
Verwenden
Oseltamivir Acid (Oseltamivir EP Impurity C) is a metabolite of Oseltamivir (O701000). It is a COVID19-related research product.
Definition
ChEBI: A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). A antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.
Einzelnachweise
[1] enguang feng, deju ye, jian li, dengyou zhang, jinfang wang, fei zhao, rolf hilgenfeld, mingyue zheng, hualiang jiang and hong liu. recent advances in neuraminidase inhibitor development as anti-influenza drugs. chem med chem 2012, 7: 1527 – 1536.
[2] tom jefferson reviewer, mark jones, peter doshi, elizabeth a spencer, igho onakpoya, carl j heneghan. oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comment. bmj. 2014, 348: g2545.
[3] rashmi dixit, gulam khandaker, scott ilgoutz, harunor rashid and robert booy. emergence of oseltamivir resistance: control and management of influenza before, during and after the pandemic. infectious disorders – drug targets. 2013, 13 (1): 34-45.

OSELTAMIVIR ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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