8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Struktur

Dinatrium-8-hydroxy-7-[(6-sulfonato-2-naphthyl)azo]chinolin-5-sulfonat

Bezeichnung:Dinatrium-8-hydroxy-7-[(6-sulfonato-2-naphthyl)azo]chinolin-5-sulfonat

Englisch Name:8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt

CBNumberCB6408024

SummenformelC19H11N3Na2O7S2

Molgewicht503.42

Synonyma

Dinatrium-8-hydroxy-7-[(6-sulfonato-2-naphthyl)azo]chinolin-5-sulfonat

Dinatrium-8-hydroxy-7-[(6-sulfonato-2-naphthyl)azo]chinolin-5-sulfonat physikalisch-chemischer Eigenschaften

storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	water: 10 mg/mL
Aggregatzustand	Solid
Farbe	Brown to black
Wasserlöslichkeit	water: 10mg/mL
InChIKey	YOGRUDWAJPVHEL-LLDDCTHSSA-L
SMILES	[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1
EPA chemische Informationen	5-Quinolinesulfonic acid, 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-, disodium salt (56932-43-5)

Sicherheit

8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
dark red to red-brown powder
Verwenden
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Biologische Aktivität
Cell permeable: yes', 'Primary Target
SHP1/2 PTPase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
in vivo

NSC-87877 (30mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity^[3].
Animal Model: Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice^[3].
Dosage: 30mg/kg.
Administration: IP once daily for 15 days.
Result: Significantly inhibited NB tumor growth.
Einzelnachweise
[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207

Send Inquriy

Animal Model:	Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice^[3].
Dosage:	30mg/kg.
Administration:	IP once daily for 15 days.
Result:	Significantly inhibited NB tumor growth.