TETRACYCLINE PHOSPHATE COMPLEX Struktur

Metaphosphorsure, Natriumsalz, Verbindung mit [4S-(4α,4aα,5aα,6β,12aα)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacencarboxamid

Bezeichnung:Metaphosphorsure, Natriumsalz, Verbindung mit [4S-(4α,4aα,5aα,6β,12aα)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacencarboxamid

CAS-Nr1336-20-5

Englisch Name:TETRACYCLINE PHOSPHATE COMPLEX

CBNumberCB6394554

SummenformelC22H27N2O12P

Molgewicht542.43

MOL-Datei1336-20-5.mol

Synonyma

Metaphosphorsure, Natriumsalz, Verbindung mit [4S-(4α,4aα,5aα,6β,12aα)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacencarboxamid

Metaphosphorsure, Natriumsalz, Verbindung mit [4S-(4α,4aα,5aα,6β,12aα)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacencarboxamid physikalisch-chemischer Eigenschaften

storage temp.	−20°C
Aggregatzustand	powder
Farbe	yellow to yellow with an orange cast

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25-40
S-Sätze:	22-36-45
WGK Germany	3

Gefahreninformationscode (GHS)

TETRACYCLINE PHOSPHATE COMPLEX Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Tetrex,Bristol,US,1956
Verwenden
Tetracycline phosphate complex is an antibiotic useful in an array of bioassays.
Manufacturing Process
In a 500-ml round-bottomed flask equipped with stirrer, condenser and thermometer was placed 7.1 grams (0.05 mol) P2O5 which was immediately covered with 100 ml of chloroform. To the mixture was added with stirring 0.9 ml (0.05 mol) of distilled water. In a few minutes, a lower oily layer appeared, which was believed to be freshly formed metaphosphoric acid resulting from the action of the P2O5 with an equimolar amount of water. To this mixture was added 100 ml of methanol and on continued stirring, the lower oily layer disappeared in the methanol forming a complete pale yellowish-green colored solution.
An additional 50 ml of methanol was added to the flask and then 22.2 grams (0.05 mol) of tetracycline, neutral form, was added portionwise intermittently with another 50 ml of methanol. A clear solution was maintained throughout the addition of the tetracycline. After addition of all of the tetracycline, the solution was a deep orange color and the temperature in the reaction flask was 35°C.
One hour after addition of the tetracycline, the clear reaction solution was poured into 1,500 ml of chloroform. A yellow product separated and was collected on a coarse sintered glass filter and air dried. The tetracyclinemetaphosphoric acid complex weighed about 10 grams, contained 7.34% of phosphorus and had a bioassay of 634 gammas per milligram. Solubility in water is 750 mg/ml.
Therapeutic Function
Antibacterial

TETRACYCLINE PHOSPHATE COMPLEX Upstream-Materialien And Downstream Produkte

Metaphosphorsure, Natriumsalz, Verbindung mit [4S-(4α,4aα,5aα,6β,12aα)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacencarboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1336-20-5, TETRACYCLINE PHOSPHATE COMPLEX Verwandte Suche:

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