NPGB Struktur

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid

Bezeichnung:4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid

CAS-Nr19135-17-2

Englisch Name:NPGB

CBNumberCB6287205

SummenformelC14H13ClN4O4

Molgewicht336.73

MOL-Datei19135-17-2.mol

Synonyma

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	241-243 °C
storage temp.	-20°C
BRN	8024554

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	26
WGK Germany	3
F	8-10

Gefahreninformationscode (GHS)

NPGB Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
Allgemeine Beschreibung
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
Biochem/physiol Actions
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
Einzelnachweise
[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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