8-OXO-2'-DEOXYGUANOSINE

Bezeichnung:8-OXO-2'-DEOXYGUANOSINE

CAS-Nr88847-89-6

Englisch Name:8-OXO-2'-DEOXYGUANOSINE

CBNumberCB6269667

SummenformelC10H13N5O5

Molgewicht283.24

MOL-Datei88847-89-6.mol

8-OXO-2'-DEOXYGUANOSINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	217-220°C
Dichte	2.25±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (up to 10 mg/ml).
pka	7.86±0.20(Predicted)
Aggregatzustand	White to off-white solid.
Farbe	Off-white
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Sicherheit

S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	MF8782675
HS Code	29349990

Gefahreninformationscode (GHS)

8-OXO-2'-DEOXYGUANOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3
Chemische Eigenschaften
White Crystalline Solid
Verwenden
8-Hydroxy-2′-deoxyguanosine has been used:
- as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
- as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
- as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
- as a standard for LC/MS/MS analysis
Verwenden
A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
Definition
ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.
Biochem/physiol Actions
A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis
Einzelnachweise
1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636 2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221 3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41

8-OXO-2'-DEOXYGUANOSINE Upstream-Materialien And Downstream Produkte

8-OXO-2'-DEOXYGUANOSINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

88847-89-6, 8-OXO-2'-DEOXYGUANOSINE Verwandte Suche:

Send Inquriy