SteMRegenin 1

Bezeichnung:SteMRegenin 1

CAS-Nr1227633-49-9

Englisch Name:SteMRegenin 1

CBNumberCB62560979

SummenformelC24H23N5OS

Molgewicht429.54

MOL-Datei1227633-49-9.mol

SteMRegenin 1 physikalisch-chemischer Eigenschaften

Siedepunkt	604.9±65.0 °C(Predicted)
Dichte	1.36±0.1 g/cm3(Predicted)
storage temp.	+2C to +8C
Löslichkeit	Soluble in DMSO (up to 10 mg/ml).
Aggregatzustand	White solid
pka	10.03±0.15(Predicted)
Farbe	Off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey	BGFHMYJZJZLMHW-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
HS Code	2934999090

Gefahreninformationscode (GHS)

SteMRegenin 1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
SR1 (1227633-49-9)?extends the pluripotency of hematopoietic stem cells by antagonizing the arylhydrocarbon receptor (AhR), IC50?= 127?nM.1?The effect is dose-dependent and reversible. Displays a biphasic effect on CD34-negative cells with low does (1 μM) enhancing proliferation and high does (>5 μM) repressing proliferation.2?May be used to generate progenitor T cells3?from HSPCs as well as NK cells for immuno-oncology studies4.
Application
StemRegenin 1 can also be used to treat infectious diseases such as HIV/AIDS, malaria, and tuberculosis. The mechanism by which StemRegenin 1 stimulates the production of new red blood cells is not well understood; however, it appears to work through activation of JAK1. This protein inhibits the polymerase chain reaction (PCR), which is an enzyme that increases the rate at which DNA copies are made from a template molecule. Inhibitors of this enzyme have been shown to prevent infection with Human Immunodeficiency Virus (HIV) in vitro.
Allgemeine Beschreibung
A cell-permeable purine compound that acts as a high affinity AhR antagonist (IC₅₀ = 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), but not a panel of 61 kinases. AhR expression and function knockouts by shRNAs, CH-223191 (Cat. No. 182705), or SR1 treatment all result in enhanced and sustained CD34⁺ population in long-term proliferating/expanding cultures of cord blood-derived HSCs (hematopoietic setem cells) in serum-free media containing Tpo (Cat. No. 605218), SCF (Cat. No. 569600), Flt3 Ligand (Cat. No. 343010), and IL-6 (Cat. No. 407652) in a reversible manner. SR1 is reactive toward human, monkey, and canine, but not rat or murine, species.
Verwenden
StemRegenin 1 is a plant-derived stem cell factor that is potent inducers of hematopoietic stem cells. It has been shown to stimulate the differentiation and proliferation of primary cells, such as human umbilical cord blood cells and bone marrow cells, into mature erythrocytes and leukocytes.
target
AhR
Lager
Store at -20°C
Einzelnachweise
1) Boitano?et al.?(2010),?Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells; Science,?329?1354 2) Tao?et al.?(2017),?StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells; J. Stem Cells Regen. Med.,?13?75 3) Singh?et al.?(2019),?Generation and function of progenitor T cells from stemRegenin-1-expanded CD34+ human hematopoietic progenitor cells;?Blood Adv,?3?2934 4) Hoogstad-van Evert?et al.?(2017),?Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull?mice; Oncoimmunology,?6(8)?e1320630

SteMRegenin 1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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