FH 535

Bezeichnung:FH 535

CAS-Nr108409-83-2

Englisch Name:FH 535

CBNumberCB62552602

SummenformelC13H10Cl2N2O4S

Molgewicht361.2

MOL-Datei108409-83-2.mol

FH 535 physikalisch-chemischer Eigenschaften

Schmelzpunkt	141-142℃
Siedepunkt	526.3±60.0 °C(Predicted)
Dichte	1.566±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble20mg/mL
Aggregatzustand	Yellow solid
pka	5.83±0.10(Predicted)
Farbe	Tan
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey	AXNUEXXEQGQWPA-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	41
S-Sätze:	36
WGK Germany	3
HS Code	29350090

Gefahreninformationscode (GHS)

FH 535 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4
Chemische Eigenschaften
Dark Yellow Solid
Verwenden
Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.
Verwenden
A cell-permeable compound that inhibits Wnt/β-catenin and PPAR
Definition
ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide.
Biochem/physiol Actions
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
Lager
+4°C
Einzelnachweise
1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521 2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418 3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187 4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380 5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880

FH 535 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

108409-83-2, FH 535 Verwandte Suche:

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