Lufenuron

Bezeichnung:Lufenuron

CAS-Nr103055-07-8

Englisch Name:Lufenuron

CBNumberCB6229074

SummenformelC17H8Cl2F8N2O3

Molgewicht511.15

MOL-Datei103055-07-8.mol

Lufenuron physikalisch-chemischer Eigenschaften

Schmelzpunkt	174.1°
Dichte	1.631±0.06 g/cm3(Predicted)
Dampfdruck	<0.4 x10 -3 Pa (25 °C)
Flammpunkt	170 °C
storage temp.	0-6°C
Löslichkeit	100mg/L in organic solvents at 20 ℃
Aggregatzustand	Solid
Wasserlöslichkeit	<0.06 mg l^-1(25 °C)
pka	8.49±0.46(Predicted)
Farbe	Off-white to light yellow
JECFA Number	85
BRN	8398291
InChIKey	PWPJGUXAGUPAHP-UHFFFAOYSA-N
LogP	5.12 at 25℃
CAS Datenbank	103055-07-8(CAS DataBase Reference)
EPA chemische Informationen	Benzamide, N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluoro- (103055-07-8)

Sicherheit

Kennzeichnung gefährlicher	Xi;N,N,Xi
R-Sätze:	43-50/53
S-Sätze:	2-24-37-60-61
RIDADR	3077
WGK Germany	2
HazardClass	9
PackingGroup	III
HS Code	29242990
Toxizität	LD50 in rats (mg/kg): >2000 orally; LC50 in rats (mg/m3): >2350 (Buholzer)

Gefahreninformationscode (GHS)

Lufenuron Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S2:Darf nicht in die Hände von Kindern gelangen.
S24:Berührung mit der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Lufenuron is an insect development inhibitor of the benzoylphenyl urea class. It demonstrates activity against fleas that have fed on treated cats and dogs and become exposed to lufenuron in the host’s blood. Lufenuron also has activity by virtue of its presence in adult flea feces, leading to its ingestion by flea larvae. Both activities result in the production of eggs that are unable to hatch, causing significant reductions in flea larvae populations. The lipophilicity of lufenuron leads to its deposition in adipose tissues of animals from where it is slowly released into the bloodstream. This permits effective blood concentrations to be maintained throughout the recommended oral dosing interval of 1 month.
Verwenden
Lufenuron is used for the control of Lepidoptera and Coleoptera larvae on cotton, maize and vegetables, and of citrus whitefly and rust mites on citrus fruit. It is also used to control fleas on pets and cockroaches in houses.
Definition
ChEBI: Lufenuron is a benzoylurea insecticide, a dichlorobenzene, a N-acylurea, an aromatic ether and an organofluorine compound.
Flammability and Explosibility
Not classified
Pharmakologie
Antiparasitic. Lufenuron is a benzoylurea insecticide. This class of insecticides was previously used on fruits to decrease damage by insects. Lufenuron (Program) has been used for prevention of flea infections in dogs and cats because it inhibits chitin synthesis. For this use, it has been given to dogs at a dose of 10 mg/kg every 30 days and to cats at a dose of 30 mg/kg every 30 days. It may also have some inhibition on fungal cell membranes because it inhibits the cell wall of fungi, which contain chitin, and other complex polysaccharides. Because of this property on fungal cell membranes, there has been interest in using lufenuron to treat dermatophytes in small animals. However, proven efficacy has been controversial. Well-controlled studies have not confirmed consistent efficacy for treating dermatophytes in animals.
Veterinary Drugs and Treatments
Lufenuron is approved for use in dogs and cats 6 weeks of age and older for the control of flea populations. The combination product of lufenuron and milbemycin (Sentinel?) is indicated for use in puppies and dogs 4 weeks and older for prevention and control flea populations, prevention of heartworm disease, control of adult hookworms, and the removal and control of adult roundworms and whipworms.
Lufeneron showed initial promise as a treatment for fungal infections, but the early enthusiasm has dampened considerably as efficacy appears doubtful.
Stoffwechselwegen
Only limited information is available in the open literature on the metabolism of lufenuron.
Degradation
Lufenuron is less stable at alkaline pH than under acidic conditions. The DT₅₀ at 25 °C is 160 days at pH 5,70 days at pH 7 and 32 days at pH 9 (PM).
Mode of action
Lufenuron has no systemic or translaminar effect. It is persistent with a transovarial effect. It may reduce the egg-Iaying rate or hinder the hatching process of embryos.

Lufenuron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

103055-07-8, Lufenuron Verwandte Suche:

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