2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Struktur

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

Bezeichnung:2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

CAS-Nr299442-43-6

Englisch Name:2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

CBNumberCB6144364

SummenformelC12H11N3O2

Molgewicht229.23

MOL-DateiMol file

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE physikalisch-chemischer Eigenschaften

Siedepunkt	464.9±47.0 °C(Predicted)
Dichte	1.360±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO or methanol
Aggregatzustand	powder
pka	1.85±0.40(Predicted)
Farbe	off-white to light brown
Sensitive	Light Sensitive
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	25
S-Sätze:	45
WGK Germany	3
HazardClass	IRRITANT

Gefahreninformationscode (GHS)

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4
Verwenden
NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures.
Allgemeine Beschreibung
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀ = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Biochem/physiol Actions
Cell permeable: yes
Lager
Store at +4°C
Einzelnachweise
1) Onda?et al. (2001),?Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem.,?276?47785 2) Pierre?et al. (2009),?Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov.,?8?321 3) Brand?et al. (2013),?Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap.,?347?265 4) Oritz-Capisano?et al. (2007),?Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension,?49?618

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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