H3B-120 Struktur

H3B-120

Bezeichnung:H3B-120

Englisch Name:H3B-120

CBNumberCB56193507

SummenformelC19H24N4O2S

Molgewicht372.48

H3B-120 physikalisch-chemischer Eigenschaften

H3B-120 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität
H3B-120 is a competitive and selective allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits antitumor activity.
in vitro

H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
It achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
Also H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.

target

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