TG003

Bezeichnung:TG003

CAS-Nr300801-52-9

Englisch Name:TG003

CBNumberCB5505045

SummenformelC13H15NO2S

Molgewicht249.33

MOL-Datei300801-52-9.mol

TG003 physikalisch-chemischer Eigenschaften

Schmelzpunkt	132-132.5 °C
Siedepunkt	386.0±42.0 °C(Predicted)
Dichte	1.237±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: 33 mg/mL
Aggregatzustand	solid
pka	-1.76±0.20(Predicted)
Farbe	pale yellow
Sensitive	Light Sensitive

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

TG003 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC₅₀ values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC₅₀ = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.
Verwenden
TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.
Verwenden
TG003 has been used in PAC1 cell culture and in vitro kinase assays.
Verwenden
Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.
Biochem/physiol Actions
TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

TG003 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

300801-52-9, TG003 Verwandte Suche:

Send Inquriy