Triparanol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H318：Verursacht schwere Augenschäden.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

TRIPARANOL Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R41:Gefahr ernster Augenschäden.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S39:Schutzbrille/Gesichtsschutz tragen.

• Originator

  Mer-29,Merrell National,US,1960

• Verwenden

  Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts¹. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (I_ks) channels².

• Verwenden

  Desmosterol Delta 24 (D24) reductase inhibitor

• Definition

  ChEBI: Triparanol is a stilbenoid. It has a role as an anticoronaviral agent.

• Manufacturing Process

  4-(β-diethylaminoethoxy)-4-methylbenzophenone was prepared as follows: a mixture of 200 g of 4-hydroxy-4-methylbenzophenone, 55 g of powdered sodium methoxide and 400 ml of ethanol was stirred for 30 minutes. A solution of 150 g of β-diethylaminoethyl chloride in 300 ml of toluene was added and the mixture was refluxed four hours. The solvent was removed, the residue was taken up in ether, extracted with 5% NaOH solution, twice with water, the ether was removed and the residue was distilled. The product was obtained as an oil boiling at 232°C at 0.6 mm.
  1 liter of a 0.45 N ethereal solution of p-chlorobenzyl magnesium chloride was added in 30 minutes to a stirred solution of 104 g (0.35 mol) of 4-(β- diethylaminoethoxy)-4-methylbenzophenone in 400 ml of dry ether. After stirring an additional hour, the mixture was decomposed by pouring onto 1 liter of cold 10% ammonium chloride solution, the ether solution was washed with water, and the ether was replaced with hot isopropanol containing a trace of ammonia. 1-[p-(β-diethylaminoethoxy)phenyl]-1-phenyl-2-p-tolyl-2-p_x0002_chloroethanol separated as white crystals, melting at 104% to 106°C.

• Therapeutic Function

  Antihyperlipidemic

• Biochem/physiol Actions

  Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.

TRIPARANOL Upstream-Materialien And Downstream Produkte

Triparanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(34)Suppliers

78-41-1, TRIPARANOL Verwandte Suche: