HOE-140 Struktur

HOE-140

Bezeichnung:HOE-140

CAS-Nr138614-30-9

Englisch Name:HOE-140

CBNumberCB5497052

SummenformelC59H89N19O13S.C2H4O2

Molgewicht1364.59

MOL-Datei138614-30-9.mol

HOE-140 physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM) Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM)
Aggregatzustand	A crystalline solid
Farbe	White to off-white

Sicherheit

WGK Germany

HOE-140 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a K_i of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.
Originator
Jerini (Germany)
Verwenden
Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).
Verwenden
Antagonist (bradykinin).
Definition
ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.
Trademarks
Metastat (CollaGenex);Firazyr.
Biochem/physiol Actions
B2 bradykinin receptors are present in the sensory neurons. Activation of B2 receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B2 bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.
Synthese
The peptidomimetic is prepared by standard solidphase technology on Wang resin employing Fmoc chemistry. Following trifluoroacetic acid cleavage with appropriate scavengers and HPLC purification, icatibant is ultimately isolated as its acetate salt.

HOE-140 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

138614-30-9, HOE-140 Verwandte Suche:

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