HDAC6-IN-1

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

HDAC6-IN-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  SKLB-23bb is an orally bioavailable and selective HDAC6 inhibitor with IC50 of less than 100 nM in most cell lines tested; it can be used to disrupt microtubule activity.

• in vitro

  SKLB-23bb has toxic effects at low submolar levels in a range of solid and hematological tumor cell lines. Unlike reported selective HDAC6 inhibition, SKLB-23bb is more potent against solid tumors. SKLB-23bb selectively inhibits intracellular HDAC6, but its antitumor activity is independent of HDAC6. It can bind to the colchicine site of β-tubulin and is a microtubule polymerization inhibitor. SKLB-23bb also can arrest tumor cells in the G2-M phase and induce apoptosis.

• in vivo

  In a solid tumor model, oral administration of SKLB-23bb can effectively inhibit tumor growth. It has favorable pharmacokinetic properties and is orally active.

• target

  Target	Value
  HDAC6 (Cell-based assay)	<100 nM

HDAC6-IN-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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