2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

Bezeichnung:2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

CAS-Nr29166-72-1

Englisch Name:2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

CBNumberCB5464951

SummenformelC9H21N3

Molgewicht171.28

MOL-Datei29166-72-1.mol

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE physikalisch-chemischer Eigenschaften

Siedepunkt	88-89 °C/43 mmHg (lit.)
Dichte	0.85
Brechungsindex	n20/D 1.457
Flammpunkt	65 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Aggregatzustand	clear liquid
pka	13.81±0.70(Predicted)
Farbe	Colorless to Light yellow
BRN	2352408
InChIKey	YQHJFPFNGVDEDT-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	22-34
S-Sätze:	26-36/37/39-45
RIDADR	UN 3267 8/PG 2
WGK Germany	3
F	10-34
HS Code	2925.29.7000

Gefahreninformationscode (GHS)

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.
synthetische
To an ovendried, 500-mL, three-necked, round-bottomed flask, equipped with a nitrogen inlet with gas bubbler, magnetic stirring bar, thermometer, condenser, and a 250-mL dropping funnel, were added triphosgene (14.8 g, 0.05 mol) and anhydrous toluene (120 mL). The mixture was kept under argon and cooled to ca. 10 C° with the aid of an external ice bath. A solution of N,N,N,N-tetramethylurea (18.0 mL, 0.15 mol) in dry toluene (50 mL) was then slowly added over a period of 30 min. After completion of the addition, the mixture was allowed to warm to ambient temperature, and stirring was continued for a further 1 h. During this time, a white precipitate formed, consisting of the Vilsmeier salt. Then, tert-butylamine (47.3 mL, 0.45 mol) was slowly added to the mixture over a period of 30 min. After completion of the addition, the mixture was heated under reflux for 5 h and then cooled to room temperature. Anhydrous diethyl ether (200 mL) was added and the white precipitate was quickly removed by filtration. This precipitate had to be collected as quickly as possible to avoid hydrolysis to the starting urea. The precipitate turns pale-yellow if hydrolysis is occurring. In some instances, additional diethyl ether (300 mL) was needed to ensure complete transfer of the solids to the filtration apparatus. The precipitate was washed with a further quantity of anhydrous diethyl ether (300 mL) (the filtrate must be colorless, indicating that all impurities have been removed) and immediately dissolved in aqueous 25% sodium hydroxide solution (100 mL). The mixture was then extracted with diethyl ether (3 × 300 mL). The combined organic layers were dried (potassium carbonate), filtered, and the solvent was removed under reduced pressure. The resulting colorless liquid was purified by distillation (bp 88–89 C°/36 mmHg) to afford 18.7 g (73%) of 2-tertbutyl- 1,1,3,3-tetramethylguanidine 1779.
Allgemeine Beschreibung
2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Upstream-Materialien And Downstream Produkte

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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